https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50144 Wed 13 Mar 2024 08:54:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39237 -/-) mice were reported to exhibit subtle deficit in recall memory. Here, we subjected 3 months old male C3aR^-/- mice to a battery of behavioral tests and examined their brain morphology. We found that the C3aR^-/- mice exhibit a short-term memory deficit and increased locomotor activity, but do not show any signs of autistic behavior as assessed by self-grooming behavior. We also found regional differences between the C3aR^-/- and wild-type (WT) mice in the morphology of motor and somatosensory cortex, as well as amygdala and hippocampus. In summary, constitutive absence of C3aR signaling in mice leads to neurodevelopmental abnormalities that persist into adulthood and are associated with locomotive hyperactivity and altered cognitive functions.]]> Fri 27 May 2022 13:50:26 AEST ]]>